
Search Clinical Trials
Below please find a list of studies actively recruiting volunteers at one of the following GHUCCTS institutions: Georgetown University, Howard University, MedStar Health Research Institute, or Washington DC VA Medical Center. Please enter your search criteria below to help find a study for you. If you have any questions, please email us or call us at 301-560-2963.
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Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With...
Children's Oncology Group
Carcinoma In Situ
Hematopoietic and Lymphoid System Neoplasm
Malignant Solid Neoplasm
This randomized clinical phase III trial studies how well web-based physical activity
intervention works in improving long term health in children and adolescents with cancer.
Regular physical activity after receiving treatment for cancer may help to maintain a healthy
weight... expand
This randomized clinical phase III trial studies how well web-based physical activity intervention works in improving long term health in children and adolescents with cancer. Regular physical activity after receiving treatment for cancer may help to maintain a healthy weight and improve energy levels and overall health. Type: Interventional Start Date: Aug 2017 |
Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Patients With Thyroid...
Blueprint Medicines Corporation
RET-altered Non Small Cell Lung Cancer
Medullary Thyroid Cancer
RET-altered Papillary Thyroid Cancer
RET-altered Colon Cancer
RET-altered Solid Tumors
This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety,
tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic
activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid... expand
This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors. Type: Interventional Start Date: Mar 2017 |
A Study to Test Combination Treatments in Patients With Advanced Gastric Cancer
Bristol-Myers Squibb
Advanced Gastric Cancer
The purpose of this study is to determine whether Nivolumab in combination with other
therapies is more effective than Nivolumab in combination with Ipilimumab in treating
patients/subjects with advanced gastric cancer.
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The purpose of this study is to determine whether Nivolumab in combination with other therapies is more effective than Nivolumab in combination with Ipilimumab in treating patients/subjects with advanced gastric cancer. Type: Interventional Start Date: Nov 2016 |
A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma
National Cancer Institute (NCI)
Metastatic Cutaneous Melanoma
Stage III Cutaneous Melanoma AJCC v7
Stage IIIA Cutaneous Melanoma AJCC v7
Stage IIIB Cutaneous Melanoma AJCC v7
Stage IIIC Cutaneous Melanoma AJCC v7
This phase II/III trial studies the side effects of nivolumab and ipilimumab when given
together with or without sargramostim and to see how well they work in treating patients with
stage III-IV melanoma that cannot be removed by surgery (unresectable). Immunotherapy with... expand
This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. It is not yet known whether nivolumab and ipilimumab are more effective with or without sargramostim in treating patients with melanoma. Type: Interventional Start Date: Sep 2015 |
HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network
University of North Carolina, Chapel Hill
Hepatitis C
The primary purpose of the HCV-TARGET study is to establish a nationwide registry of patients
undergoing treatment with antiviral therapies for chronic hepatitis C (HCV) at both academic
and community practices.
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The primary purpose of the HCV-TARGET study is to establish a nationwide registry of patients undergoing treatment with antiviral therapies for chronic hepatitis C (HCV) at both academic and community practices. Type: Observational Start Date: Nov 2011 |
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
QuantumLeap Healthcare Collaborative
Breast Neoplasms
Breast Cancer
Breast Tumors
Angiosarcoma
The purpose of this study is to further advance the ability to practice personalized medicine
by learning which new drug agents are most effective with which types of breast cancer tumors
and by learning more about which early indicators of response (tumor analysis prior to... expand
The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging (MRI) images along with tissue and blood samples) are predictors of treatment success. Type: Interventional Start Date: Mar 2010 |
CO2 Laser Revision for Burn Related Donor Site Scars
Medstar Health Research Institute
Burn Scar
Scar
Skin Graft Scar
Scarring from burn wounds remains a chronic and often severe sequela of burn injury. Burn
wounds may be left to heal by secondary intention or treated with surgical skin grafting; in
both circumstances, significant scars likely result. When surgical skin grafting is employed,... expand
Scarring from burn wounds remains a chronic and often severe sequela of burn injury. Burn wounds may be left to heal by secondary intention or treated with surgical skin grafting; in both circumstances, significant scars likely result. When surgical skin grafting is employed, skin graft harvest sites ("donor sites") likewise result in clinically significant scars. This study will have interventional and observational components. Patients will receive the standard fractional ablative CO2 treatments to their scars resulting from burn wounds allowed to heal by secondary intention and/or those treated with skin grafts. These will be prospectively observed for the duration of the study as well as adjacent normal skin. In addition, a donor site that meets inclusion criteria that would not have otherwise received LSR will be identified as a treatment site. Patients with have one half of their donor sites randomized to standard of care (SOC) treatment, which consists of wound dressings, compression therapy, physical and occupational therapies and the other half randomized to SOC + ablative fractional CO2 laser therapy (LSR). Type: Interventional Start Date: Jan 2020 |
Metta Meditation Training on Prosocial Behavior
Georgetown University
Social Behavior
The purpose of the study is to look at the impact of a metta meditation training on prosocial
behavior and socio-affective brain responses. The training involves an 8-week, online
administration of guided metta meditation practices aimed at generating feelings of kindness... expand
The purpose of the study is to look at the impact of a metta meditation training on prosocial behavior and socio-affective brain responses. The training involves an 8-week, online administration of guided metta meditation practices aimed at generating feelings of kindness and compassion for other people. The study examines how participants respond to thinking about familiar others and strangers using behavioral and brain-imaging measures. This study will be important for understanding how people develop the capacity to be prosocial towards other individuals, which is a key component of adaptive social behavior. Type: Interventional Start Date: Sep 2018 |
Apixaban in Preventing Secondary Cancer Related Venous Thrombosis in Cancer Patients Who Have Completed...
Academic and Community Cancer Research United
Cerebral Vein Thrombosis
Deep Vein Thrombosis
Malignant Neoplasm
Metastatic Malignant Neoplasm
Pulmonary Embolism
This randomized phase III trial studies the best dose of apixaban and how well it works in
preventing secondary cancer related venous thrombosis in cancer patients who have completed
anticoagulation therapy. Apixaban may help in prevention by blocking some of the enzymes
needed... expand
This randomized phase III trial studies the best dose of apixaban and how well it works in preventing secondary cancer related venous thrombosis in cancer patients who have completed anticoagulation therapy. Apixaban may help in prevention by blocking some of the enzymes needed for venous thrombosis. Type: Interventional Start Date: Jul 2017 |
Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia...
Children's Oncology Group
Acute Lymphoblastic Leukemia
B Acute Lymphoblastic Leukemia
Mixed Phenotype Acute Leukemia
T Acute Lymphoblastic Leukemia
This randomized phase III trial studies how well imatinib mesylate and combination
chemotherapy work in treating patients with newly diagnosed Philadelphia chromosome positive
acute lymphoblastic leukemia. Imatinib mesylate may stop the growth of cancer cells by
blocking some... expand
This randomized phase III trial studies how well imatinib mesylate and combination chemotherapy work in treating patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia. Imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving imatinib mesylate and combination chemotherapy may work better in treating patients with Philadelphia chromosome positive acute lymphoblastic leukemia. Type: Interventional Start Date: Jul 2017 |
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy...
National Cancer Institute (NCI)
Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma
Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7
Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7
Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7
This phase II/III trial studies how well radiation therapy works when given together with
cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with
high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous
cell).... expand
This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The purpose of this study is to compare the usual treatment (radiation therapy with cisplatin chemotherapy) to using radiation therapy with docetaxel and cetuximab chemotherapy, and using the usual treatment plus an immunotherapy drug, atezolizumab. Type: Interventional Start Date: Mar 2013 |
Web Based Orthopaedic Sports Medicine Registry
Arthrex, Inc.
Degenerative and Traumatic Pathology of the Knee
Degenerative and Traumatic Pathology of the Shoulder and Elbow
Degenerative and Traumatic Pathology of the Foot and Ankle
Degenerative and Traumatic Pathology of the Hand and Wrist
Degenerative and Traumatic Pathology of the Hip
The purpose of this study is to establish an international, web based clinical registry to
collect baseline characteristics of patients undergoing orthopaedic, sports medicine,
arthroscopy, and related surgery, and the subsequent outcomes and cost-effectiveness
associated... expand
The purpose of this study is to establish an international, web based clinical registry to collect baseline characteristics of patients undergoing orthopaedic, sports medicine, arthroscopy, and related surgery, and the subsequent outcomes and cost-effectiveness associated with the surgical procedures and nonoperative treatments. Type: Observational [Patient Registry] Start Date: Sep 2010 |
Gut and Intratumoral Microbiome Effect on the Neoadjuvant Chemotherapy-induced Immunosurveillance in...
Hackensack Meridian Health
Triple Negative Breast Cancer
The probability of pCR in TNBC patients receiving standard of care neoadjuvant chemotherapy
treatment is associated with the dominance of specific intestinal and intratumoral microbiota
that promote anti-tumor immunosurveillance.
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The probability of pCR in TNBC patients receiving standard of care neoadjuvant chemotherapy treatment is associated with the dominance of specific intestinal and intratumoral microbiota that promote anti-tumor immunosurveillance. Type: Observational Start Date: Aug 2017 |
Zoster Eye Disease Study
NYU Langone Health
Herpes Zoster Ophthalmicus
This is a multi-center, randomized, double-masked, placebo-controlled clinical trial of
suppressive valacyclovir for one year in immunocompetent study participants with an episode
of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis
due... expand
This is a multi-center, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to Herpes Zoster Ophthalmicus (HZO) in the year prior to enrollment. Type: Interventional Start Date: Aug 2017 |
Platinum Based Chemotherapy or Capecitabine in Treating Patients With Residual Triple-Negative Basal-Like...
ECOG-ACRIN Cancer Research Group
Estrogen Receptor Negative
HER2/Neu Negative
Invasive Breast Carcinoma
Progesterone Receptor Negative
Stage II Breast Cancer
This randomized phase III trial studies how well cisplatin or carboplatin (platinum based
chemotherapy) works compared to capecitabine in treating patients with remaining (residual)
basal-like triple-negative breast cancer following chemotherapy after surgery (neoadjuvant).... expand
This randomized phase III trial studies how well cisplatin or carboplatin (platinum based chemotherapy) works compared to capecitabine in treating patients with remaining (residual) basal-like triple-negative breast cancer following chemotherapy after surgery (neoadjuvant). Drugs used in chemotherapy, such as cisplatin, carboplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether cisplatin or carboplatin is more effective than capecitabine in treating patients with residual triple negative basal-like breast cancer. Type: Interventional Start Date: Apr 2015 |
Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by...
ECOG-ACRIN Cancer Research Group
ALK Gene Rearrangement
ALK Gene Translocation
ALK Positive
Stage IB Non-Small Cell Lung Carcinoma AJCC v7
Stage II Non-Small Cell Lung Cancer AJCC v7
This randomized phase III trial studies how well crizotinib works in treating patients with
stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation
in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make... expand
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation. Type: Interventional Start Date: Aug 2014 |
Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS
Alliance Foundation Trials, LLC.
DCIS
Ductal Carcinoma in Situ
This study looks at the risks and benefits of active monitoring (AM) compared to surgery in
the setting of a pragmatic prospective randomized trial for low risk DCIS. Our overarching
hypothesis is that management of low-risk Ductal Carcinoma in Situ (DCIS) using an AM
approach... expand
This study looks at the risks and benefits of active monitoring (AM) compared to surgery in the setting of a pragmatic prospective randomized trial for low risk DCIS. Our overarching hypothesis is that management of low-risk Ductal Carcinoma in Situ (DCIS) using an AM approach does not yield inferior cancer or quality of life outcomes compared to surgery. Type: Interventional Start Date: Feb 2017 |
An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab...
ModernaTX, Inc.
Melanoma
The purpose of this study is to assess whether postoperative adjuvant therapy with mRNA-4157
and pembrolizumab improves recurrence free survival (RFS) compared to pembrolizumab alone in
patients with complete resection of cutaneous melanoma and a high risk of recurrence.
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The purpose of this study is to assess whether postoperative adjuvant therapy with mRNA-4157 and pembrolizumab improves recurrence free survival (RFS) compared to pembrolizumab alone in patients with complete resection of cutaneous melanoma and a high risk of recurrence. Type: Interventional Start Date: Jul 2019 |
Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia
Georgetown University
Aphasia, Primary Progressive
Anomia
Alzheimer Disease
The goal of this study is to remediate word-finding problems in patients who have Primary
Progressive Aphasia (PPA) or Alzheimer's Disease and to delay the further progression of
word-finding impairment. The current approach is novel in that it contains a prophylaxis
component... expand
The goal of this study is to remediate word-finding problems in patients who have Primary Progressive Aphasia (PPA) or Alzheimer's Disease and to delay the further progression of word-finding impairment. The current approach is novel in that it contains a prophylaxis component in which the investigators attempt to strengthen neural connections that remain functional, making them more resistant to degradation as the disease progresses. While the study is specific in its targeting of word-finding problems, a successful outcome would bode well for other studies aimed at prevention or reversal of declining cognitive functions in dementia. One set of participants with PPA will receive practice with picture naming in two conditions: viewing the picture and repeating the name; and viewing the picture with its written name, plus reading and writing the name. Another set of participants with PPA or Alzheimer's Disease will be trained in two different conditions: learning about the word's semantic features (meaning); and learning about the word's lexical features (letters and sounds). Naming of pictures trained in each of these conditions will be compared, at three time intervals post-training, with naming of pictures tested before the study but never trained. It is predicted that the pairing of the picture with its written name, combined with the motor task of writing the name, will result in a greater ability to name the picture at a later date than simple practice viewing the picture and repeating the name. Furthermore, it is predicted that participants who have difficulty understanding concepts will be more likely to respond to semantic treatment, while participants who have difficulty connecting words with concepts will be more likely to respond to lexical treatment. Type: Interventional Start Date: Nov 2011 |
Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations
Georgetown University
Surgical Wound
Wound Heal
Amputation
The purpose of this study is to evaluate how well subjects heal after surgery who receive
standard dressings or incisional negative pressure wound therapy for non-traumatic amputation
sites.
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The purpose of this study is to evaluate how well subjects heal after surgery who receive standard dressings or incisional negative pressure wound therapy for non-traumatic amputation sites. Type: Interventional Start Date: Nov 2017 |
Check Point Inhibition After Autologous Stem Cell Transplantation in Patients at High Risk of Post Transplant...
Hackensack Meridian Health
Multiple Myeloma
Lymphoma
The goal of this study is to determine the safety and clinical effect of combined checkpoint
inhibition administered after autologous hematopoietic stem cell transplantation in each of
six clinical cohorts of high risk and recurrent disease. In addition to assessing the
incidence... expand
The goal of this study is to determine the safety and clinical effect of combined checkpoint inhibition administered after autologous hematopoietic stem cell transplantation in each of six clinical cohorts of high risk and recurrent disease. In addition to assessing the incidence and severity of adverse events and rates of complete response and progression free survival, investigators intend to monitor immune reconstitution, phenotype and TCR repertoire throughout treatment and at the time of disease progression. Investigators will also analyze the gut microbiome prior to conditioning, throughout treatment, post-transplant and at time of relapse. Type: Interventional Start Date: Jun 2016 |
Impact of CCR5 Blockade in HIV+ Kidney Transplant Recipients
National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Kidney Diseases
Maraviroc (MVC) is a type of HIV medicine called a CCR5 inhibitor. This study will evaluate
the safety and tolerability of MVC in HIV-infected adults receiving a kidney transplant.
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Maraviroc (MVC) is a type of HIV medicine called a CCR5 inhibitor. This study will evaluate the safety and tolerability of MVC in HIV-infected adults receiving a kidney transplant. Type: Interventional Start Date: Jan 2017 |
A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer
Alliance Foundation Trials, LLC.
Prostate Cancer
This is a randomized, open-label, three-arm, phase 3 study in men with biochemically
recurrent prostate cancer and PSA doubling time ≤ 9 months at the time of study entry.
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This is a randomized, open-label, three-arm, phase 3 study in men with biochemically recurrent prostate cancer and PSA doubling time ≤ 9 months at the time of study entry. Type: Interventional Start Date: Mar 2017 |
SMART Brain Health in African-Americans
Howard University
Opioid Use Disorder
Substance Use Disorders
Dopamine Dysregulation Syndrome
African Americans
The investigators hypothesize that opioid use in African-Americans will be associated with
hypodopaminergic alleles that alter the threshold for activating feelings of reward and
pleasure within the dopaminergic system, and that these allelic frequencies will differ
significantly... expand
The investigators hypothesize that opioid use in African-Americans will be associated with hypodopaminergic alleles that alter the threshold for activating feelings of reward and pleasure within the dopaminergic system, and that these allelic frequencies will differ significantly from European Americans. Planned is a targeted system to study genetic risks for reward deficiency using risk gene panel to assign a genetic addiction risk score (GARS), comprehensive surveys to determine quality of life and exposure to stressors and trauma. This system will allow prediction of addiction and relapse potential and delivery of personalized treatment. Type: Interventional Start Date: Jun 2018 |
Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection
Bolton Medical
Aortic Dissection Type B
This clinical trial is a prospective, multicenter, non-blinded, non-randomized study designed
to assess the RelayPro thoracic endografts in the treatment of acute, complicated type B
aortic dissection. The primary endpoint will measure all-cause mortality at 30 days
post-procedure.... expand
This clinical trial is a prospective, multicenter, non-blinded, non-randomized study designed to assess the RelayPro thoracic endografts in the treatment of acute, complicated type B aortic dissection. The primary endpoint will measure all-cause mortality at 30 days post-procedure. Type: Interventional Start Date: Dec 2017 |