Search Clinical Trials
Below please find a list of studies actively recruiting volunteers at one of the following GHUCCTS institutions: Georgetown University, Howard University, MedStar Health Research Institute, or Washington DC VA Medical Center. Please enter your search criteria below to help find a study for you. If you have any questions, please email us or call us at 301-560-2963.
Sponsor Condition of Interest |
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Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
VA Office of Research and Development
Prediabetic State
Atherosclerosis
Metformin
This research will help us to learn if the medicine called metformin reduces the risk of
death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood
vessel problems. expand
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems. Type: Interventional Start Date: Apr 2023 |
Project: Every Child for Younger Patients With Cancer
Children's Oncology Group
Adrenal Gland Pheochromocytoma
Carcinoma In Situ
Central Nervous System Neoplasm
Childhood Immature Teratoma
Childhood Langerhans Cell Histiocytosis
This study gathers health information for the Project: Every Child for younger patients
with cancer. Gathering health information over time from younger patients with cancer may
help doctors find better methods of treatment and on-going care. expand
This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care. Type: Observational Start Date: Nov 2015 |
Technical Development of Cardiovascular Magnetic Resonance Imaging
National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Disease
Background:
In the U.S., over 6.5 million people have heart failure. Researchers want to develop new
testing methods for cardiovascular problems using magnetic resonance imaging (MRI) to
improve the clinical diagnosis and management of people with heart failure.
Objective:
To develop and test... expand
Background: In the U.S., over 6.5 million people have heart failure. Researchers want to develop new testing methods for cardiovascular problems using magnetic resonance imaging (MRI) to improve the clinical diagnosis and management of people with heart failure. Objective: To develop and test new methods for imaging the heart and blood vessels using MRI. Eligibility: People ages 18 years and older who are having an MRI of their heart or blood vessels. Healthy volunteers are also needed. Design: Participants will be screened with a medical history. Participants will have a physical exam and blood tests. They will have an electrocardiogram (ECG) to measure the heart s electrical activity. Then they will have their scheduled MRI scan. The MRI scanner is a large, hollow tube. Participants will lie on a table that moves in and out of the tube. During the MRI, they may have contrast dye injected through an intravenous line inserted into their arm or hand. ECG may be used to monitor their heartbeat or coordinate pictures with their heartbeat. A flexible belt may be used to monitor their breathing. A finger probe may be used to track their heart rate and/or oxygenation level. Their blood pressure may be measured. Pictures may be taken of their blood vessels, heart, and lungs before, during, and after they get medicine to increase blood flow. They may lie flat and pedal a stress bicycle to increase their heart rate. Participation will last for 5 years. During that time, participants may receive a yearly survey about their health. They may be contacted for an optional follow-up MRI within 2 years of their MRI. Type: Observational Start Date: Apr 2024 |
Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
VA Office of Research and Development
Post-COVID Conditions
Obesity
The research in this VA Merit will examine the effects of obesity and Post-COVID
Conditions (PCC) on physical functioning, health-related quality of life, and adipose
tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will
evaluate whether a weight loss intervention,... expand
The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery. Type: Interventional Start Date: Jun 2024 |
Mindful Self-Compassion for Anxiety Disorders and Depression
Georgetown University
Anxiety Disorders
Generalized Anxiety Disorder
Social Anxiety Disorder
Social Phobia
Panic Disorder
The study will compare 8-week Mindful Self-Compassion training, compared to a control
group that does not receive the intervention, on anxiety and depression symptom severity
in patients with diagnosed anxiety disorders (generalized anxiety disorder, social
anxiety disorder, and panic disorder) or... expand
The study will compare 8-week Mindful Self-Compassion training, compared to a control group that does not receive the intervention, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety disorder, social anxiety disorder, and panic disorder) or major depressive disorder. Type: Interventional Start Date: Jan 2022 |
Safety and Effectiveness of Juveena™ Hydrogel System Following TCGP At High-Risk for Intrauterine Adhesions
Rejoni Inc.
Intrauterine Adhesion
This study is to determine whether intrauterine instillation of Juveena hydrogel
following adhesiogenic hysteroscopic procedures (TCGP + Juveena) can safely and
effectively reduce the incidence and severity of intrauterine adhesions (IUA) compared to
TCGP alone. expand
This study is to determine whether intrauterine instillation of Juveena hydrogel following adhesiogenic hysteroscopic procedures (TCGP + Juveena) can safely and effectively reduce the incidence and severity of intrauterine adhesions (IUA) compared to TCGP alone. Type: Interventional Start Date: Aug 2022 |
Reparixin add-on Therapy to Std Care to Limit Progression in Pts With COVID19 & Other Community Acquired...
Dompé Farmaceutici S.p.A
Infectious Pneumonia
Severe COVID-19
Primary objective:
- To evaluate the efficacy of oral reparixin versus standard care alone in limiting
disease progression in adult patients hospitalised for infectious pneumonia acquired
in the community (CAP), including COVID-19.
Secondary objectives:
- To determine the effect... expand
Primary objective: - To evaluate the efficacy of oral reparixin versus standard care alone in limiting disease progression in adult patients hospitalised for infectious pneumonia acquired in the community (CAP), including COVID-19. Secondary objectives: - To determine the effect of reparixin on several disease severity/progression measures including recovery, ventilatory free days and mortality. Safety objectives: - To evaluate the safety of oral reparixin versus placebo in the specific clinical setting. Type: Interventional Start Date: Apr 2022 |
Mitral Valve Screening Survey
Medstar Health Research Institute
Mitral Valve Disease
This study aims to examine the clinical profile/anatomical characteristics and natural
history of patients who subsequently fail screening for transcatheter mitral valve
intervention (TMVI). expand
This study aims to examine the clinical profile/anatomical characteristics and natural history of patients who subsequently fail screening for transcatheter mitral valve intervention (TMVI). Type: Observational [Patient Registry] Start Date: Aug 2021 |
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic...
National Cancer Institute (NCI)
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
This phase III trial compares early treatment with venetoclax and obinutuzumab versus
delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed
high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a
class of medications called B-cell lymphoma-2... expand
This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with the venetoclax and obinutuzumab early (before patients have symptoms) may have better outcomes for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma compared to starting treatment with the venetoclax and obinutuzumab after patients show symptoms. Type: Interventional Start Date: Mar 2021 |
Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer
ECOG-ACRIN Cancer Research Group
Breast Screening
This randomized phase III trial studies digital tomosynthesis mammography and digital
mammography in screening patients for breast cancer. Screening for breast cancer with
tomosynthesis mammography may be superior to digital mammography for breast cancer
screening and may help reduce the need for... expand
This randomized phase III trial studies digital tomosynthesis mammography and digital mammography in screening patients for breast cancer. Screening for breast cancer with tomosynthesis mammography may be superior to digital mammography for breast cancer screening and may help reduce the need for additional imaging or treatment. Type: Interventional Start Date: Sep 2017 |
Resistive Training Combined With Nutritional Therapy After Stroke
VA Office of Research and Development
Stroke
Stroke survivors experience severe muscle wasting during the chronic phase of recovery,
with implications for strength, function and general health. Although resistive exercise
training effectively combats this problem, it is unknown whether sub-optimal protein
intake limits the observed gains in... expand
Stroke survivors experience severe muscle wasting during the chronic phase of recovery, with implications for strength, function and general health. Although resistive exercise training effectively combats this problem, it is unknown whether sub-optimal protein intake limits the observed gains in skeletal muscle growth. Skeletal muscle adaptations may occur when resistive training (RT) is combined with nutritional therapy in the form of post- exercise protein consumption. This study would be the first to directly compare RT+protein supplementation to RT+placebo (same calories as protein supplement) in those with chronic hemiparesis caused by stroke, providing evidence-based rationale for combination therapy in the clinical care of this population. Type: Interventional Start Date: Aug 2015 |
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
Evon Medics LLC
Substance Use Disorders
Opioid Use Disorder
Alcohol Use Disorder
Cocaine Use Disorder
Methamphetamine-dependence
The overarching goal of this study phase, Phase II component is to implement Enhanced
Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use
Disorders (EDITOR) device in substance use disorder (SUD) clinics to demonstrate pilot
effectiveness for SUD outcomes compared... expand
The overarching goal of this study phase, Phase II component is to implement Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders (EDITOR) device in substance use disorder (SUD) clinics to demonstrate pilot effectiveness for SUD outcomes compared to treatment as usual (TAU) and Computerized Chemosensory-Based Orbitofrontal Networks Training (CBOT) device as active control. The investigators will conduct a multi-site study of 300 adult patients with opiate use disorder (OUD), stimulant (i.e., cocaine, methamphetamine) and/or alcohol use disorder (AUD) from community and clinics to evaluate whether EDITOR is associated with better patient treatment outcomes (e.g., retention in treatment and abstinence). The pilot study will provide preliminary data needed for design of a Phase III trial, including estimates of effect size. The investigators will also explore development of machine learning/AI algorithms integrating clinical and physiological data into treatment decision guides for providers. Type: Interventional Start Date: Jul 2023 |
Treatment of Hypopigmented Scars With Bimatoprost
Medstar Health Research Institute
Scars
Hypopigmented Scar
Hypopigmented Skin
Burn Scar
Scarring
Patients who have hypo-pigmented burn scar will have two scars chosen and randomized to
treated scar and control scar. The subject will then have both scars treated with
fractional ablative CO2 laser (FLSR). The treated scar will have bimatoprost delivered
through the laser channels, while the control... expand
Patients who have hypo-pigmented burn scar will have two scars chosen and randomized to treated scar and control scar. The subject will then have both scars treated with fractional ablative CO2 laser (FLSR). The treated scar will have bimatoprost delivered through the laser channels, while the control will have the vehicle (normal saline) only delivered. The treatment will continue for 14 days with twice daily application. The scars will then be monitored at a 2-week follow-up visit where levels of melanin will be evaluated. Tissue punch biopsies will also be used to evaluate the mechanism of action of bimatoprost. Treatment will occur for 6 sessions at 4-6 week intervals including follow- up visits and evaluations. Type: Interventional Start Date: Jul 2023 |
Personalized Oncology Promoting Equity for Black Lives
Rutgers, The State University of New Jersey
Hereditary Cancer
Genetic Testing
The goal of this observational study is to increase genetic education and genetic testing
for hereditary cancer risk among Black cancer survivors. The study will:
1. Test the effectiveness of a chatbot intervention (also called relational agent, or
RA) vs. enhanced usual care (EUC) on engagement... expand
The goal of this observational study is to increase genetic education and genetic testing for hereditary cancer risk among Black cancer survivors. The study will: 1. Test the effectiveness of a chatbot intervention (also called relational agent, or RA) vs. enhanced usual care (EUC) on engagement in genetic education and requests for genetic testing. 2. Evaluate the impact of the chatbot vs. EUC on the process that participants use to make decisions and evaluate effects on well-being (also called psychosocial outcomes). 3. Explore the ways (methods) that influence how participants experience the intervention. The main questions this study aims to answer are which group - the chatbot (RA) group or the EUC group - is more likely to request genetic testing and which group is more likely to get (engage with) genetic education. Participants will be randomly assigned to either the chatbot (RA) group or EUC group. This means each participant has an equal chance of being placed in either group, just like flipping a coin. Each group will receive genetic education and have an opportunity to request genetic testing. Researchers will compare the chatbot (RA) group and the EUC group to see which may request more GT (genetic testing) and which group engages more with genetic education. Type: Interventional Start Date: Feb 2024 |
A Study of Obexelimab in Patients With Warm Autoimmune Hemolytic Anemia (SApHiAre)
Zenas BioPharma (USA), LLC
Warm Autoimmune Hemolytic Anemia
This study aims to examine the efficacy and safety of obexelimab in participants with
Warm Autoimmune Hemolytic Anemia (wAIHA). expand
This study aims to examine the efficacy and safety of obexelimab in participants with Warm Autoimmune Hemolytic Anemia (wAIHA). Type: Interventional Start Date: Sep 2023 |
Fatigability in Long COVID-19
VA Office of Research and Development
Long COVID
The overall goal of this project is to advance the understanding of underlying mechanisms
impacting performance fatigability and perceived fatigability in Veterans with
post-COVID-19 fatigue and explore the safety and feasibility of a home-based
"minimal-dose" resistance exercise program in this population.... expand
The overall goal of this project is to advance the understanding of underlying mechanisms impacting performance fatigability and perceived fatigability in Veterans with post-COVID-19 fatigue and explore the safety and feasibility of a home-based "minimal-dose" resistance exercise program in this population. The central hypothesis is that declines in force capacity, skeletal muscle oxygen extraction, and affective responses to physical activity offer potential mechanisms through which fatigability is increased in Veterans with post-COVID-19 fatigue. Moreover, home-based resistance exercise delivered remotely may provide a safe and feasibility treatment option for targeting neuromuscular and neurobehavioral factors influencing fatigability severity in this population. Type: Interventional Start Date: Jul 2023 |
Cancer Parenting Program for the Enhancement of the Quality of Life of Patients With Advanced Cancer...
University of Washington
Parenting
Parent-Child Relations
Cancer
Survivorship
Hematopoietic and Lymphoid System Neoplasm
This trial examines the usefulness of two educational programs for parents with
late-stage cancer who have a 5 - 17 year old child. The programs are designed to enhance
the quality of the parent-child relationship and add to the parent's confidence in
managing the impact of their cancer on their child.... expand
This trial examines the usefulness of two educational programs for parents with late-stage cancer who have a 5 - 17 year old child. The programs are designed to enhance the quality of the parent-child relationship and add to the parent's confidence in managing the impact of their cancer on their child. Educational programs may reduce anxiety and depression and improve the well-being and quality of life of parents with advanced cancers and their children. Recruitment occurs nationally via referral to the Fred Hutch/University of Washington Cancer Consortium team. Type: Interventional Start Date: Jul 2022 |
A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer
Bristol-Myers Squibb
Carcinoma, Hepatocellular
The purpose of this study is to evaluate the safety and effectiveness of triplet therapy
of nivolumab, relatlimab and bevacizumab versus nivolumab and bevacizumab in participants
with untreated advanced/metastatic hepatocellular carcinoma (HCC). expand
The purpose of this study is to evaluate the safety and effectiveness of triplet therapy of nivolumab, relatlimab and bevacizumab versus nivolumab and bevacizumab in participants with untreated advanced/metastatic hepatocellular carcinoma (HCC). Type: Interventional Start Date: May 2022 |
Intravesical LGG VS Saline Bladder Wash RCT
Medstar Health Research Institute
Spinal Cord Injuries
Neurogenic Bladder
This is the first ever comparative effectiveness study of an antibiotic-sparing novel
self-management intervention to prevent complicated urinary tract infection (UTI). expand
This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI). Type: Interventional Start Date: Jun 2022 |
Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab)...
National Cancer Institute (NCI)
Head and Neck Squamous Cell Carcinoma
Metastatic Head and Neck Squamous Cell Carcinoma
Metastatic Hypopharyngeal Squamous Cell Carcinoma
Metastatic Laryngeal Squamous Cell Carcinoma
Metastatic Oral Cavity Squamous Cell Carcinoma
This phase II trial compares the effect of adding ipatasertib to pembrolizumab (standard
immunotherapy) vs. pembrolizumab alone in treating patients with squamous cell cancer of
the head and neck that has come back (recurrent) or that has spread from where it first
started (primary site) to other... expand
This phase II trial compares the effect of adding ipatasertib to pembrolizumab (standard immunotherapy) vs. pembrolizumab alone in treating patients with squamous cell cancer of the head and neck that has come back (recurrent) or that has spread from where it first started (primary site) to other places in the body (metastatic). Ipatasertib is in a class of medications called protein kinase B (AKT) inhibitors. It may stop the growth of tumor cells and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving ipatasertib in combination with pembrolizumab may be more effective than pembrolizumab alone in improving some outcomes in patients with recurrent/metastatic squamous cell cancer of the head and neck. Type: Interventional Start Date: Jul 2022 |
Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
Verastem, Inc.
Non Small Cell Lung Cancer
KRAS Activating Mutation
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination
with sotorasib with or without defactinib in patients with KRAS G12C Non-Small Cell Lung
Cancer (NSCLC) in patients who have been exposed to prior G12C inhibitor and those who
have not been exposed to prior G12C... expand
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with sotorasib with or without defactinib in patients with KRAS G12C Non-Small Cell Lung Cancer (NSCLC) in patients who have been exposed to prior G12C inhibitor and those who have not been exposed to prior G12C inhibitor. Type: Interventional Start Date: Apr 2022 |
Financial Navigation Program to Improve Understanding and Management of Financial Aspects of Cancer Care...
SWOG Cancer Research Network
Hematopoietic and Lymphoid Cell Neoplasm
Metastatic Malignant Solid Neoplasm
Recurrent Malignant Solid Neoplasm
This clinical trial examines a financial navigation program in helping patients (and
their spouses or partner caregivers, if participating) understand and better manage the
financial aspects of cancer care. Cancer patients and their spouse/partner caregivers may
be at high risk for financial problems... expand
This clinical trial examines a financial navigation program in helping patients (and their spouses or partner caregivers, if participating) understand and better manage the financial aspects of cancer care. Cancer patients and their spouse/partner caregivers may be at high risk for financial problems because of the cost of cancer treatment. A financial navigator is a person or team who works with patients and their families to help them reduce stress or hardship related to the cost of cancer treatment. Financial navigators help patients understand their out-of-pocket expenses and what their health insurance plans may cover. Financial navigation may also help patients set up payment plans, find cost-saving methods for treatments, and improve access to healthcare services that the patient needs. Providing financial navigation to patients may help reduce financial worries and improve quality of life. Type: Interventional Start Date: Oct 2021 |
Tiragolumab With Atezolizumab Plus Bevacizumab in Previously-Treated Advanced Non-squamous NSCLC
Georgetown University
Non-squamous Non-small-cell Lung Cancer
To evaluate the efficacy of tiragolumab with atezolizumab and bevacizumab in
previously-treated advanced non-squamous NSCLC. expand
To evaluate the efficacy of tiragolumab with atezolizumab and bevacizumab in previously-treated advanced non-squamous NSCLC. Type: Interventional Start Date: Dec 2021 |
Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters
Medstar Health Research Institute
Neurogenic Bladder
The objectives of the proposed research among this population are: 1) to define
clinically meaningful change (i.e. differentiating states of health and illness) with
respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine
ecosystem; and 2) to determine the optimal intravesical... expand
The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG®) dose to be used to reduce urinary symptoms in a future clinical trial. Type: Interventional Start Date: Jan 2020 |
IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
Medstar Health Research Institute
Atherosclerosis
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been
shown in clinical trials, registries, and meta-analyses to reduce recurrent events after
PCI. This is accomplished by improving the angiographic result with lesion and vessel
assessment to guide stent selection... expand
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been shown in clinical trials, registries, and meta-analyses to reduce recurrent events after PCI. This is accomplished by improving the angiographic result with lesion and vessel assessment to guide stent selection and implantation and intravascular imaging following stent implantation to ensure an adequate treatment endpoint has been achieved. Despite extensive literature supporting the use of IVUS in PCI, utilization remains low in the United States. An increasing number of high-risk or complex lesions are being treated with PCI and we hypothesize that the impact of IVUS in these complex lesions will be of increased importance in reducing clinical adverse events while remaining cost effective. Type: Interventional Start Date: Oct 2020 |
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