Search Clinical Trials
Below please find a list of studies actively recruiting volunteers at one of the following GHUCCTS institutions: Georgetown University, Howard University, MedStar Health Research Institute, or Washington DC VA Medical Center. Please enter your search criteria below to help find a study for you. If you have any questions, please email us or call us at 301-560-2963.
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A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy)
Merus N.V.
Solid Tumours Harboring NRG1 Fusion
NSCLC Harboring NRG1 Fusion
Pancreatic Cancer Harboring NRG1 Fusion
NRG1 Fusion
This is a Phase I/II, open-label, multi-center, multi-national, dose escalation, single
agent study to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor
activity of zenocutuzumab (MCLA-128) in patients with solid tumors harboring an NRG1
fusion (eNRGy) expand
This is a Phase I/II, open-label, multi-center, multi-national, dose escalation, single agent study to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor activity of zenocutuzumab (MCLA-128) in patients with solid tumors harboring an NRG1 fusion (eNRGy) Type: Interventional Start Date: Jan 2015 |
HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections...
Inflammatix
Respiratory Tract Infections
Urinary Tract Infections
Intra-Abdominal Infections
Skin and Soft Tissue Infection
Suspected Meningitis/Encephalitis or Any Other Infection
This study will analyze gene expression and other laboratory data from biological samples
collected from participants with suspected respiratory, urinary, intra-abdominal, and/or
skin & soft tissue infections; or suspected sepsis of any cause. expand
This study will analyze gene expression and other laboratory data from biological samples collected from participants with suspected respiratory, urinary, intra-abdominal, and/or skin & soft tissue infections; or suspected sepsis of any cause. Type: Observational Start Date: Feb 2020 |
Exercise Rehabilitation in Veteran Cancer Survivors
VA Office of Research and Development
Cancer
Exercise rehabilitation has the potential as a non-pharmacological approach to reduce
persistent neuropathic pain in Veterans with lung cancer. By examining the effects of
exercise training in Veteran cancer survivors with NSCLC, there is the potential to
revolutionize care for a: common, debilitating,... expand
Exercise rehabilitation has the potential as a non-pharmacological approach to reduce persistent neuropathic pain in Veterans with lung cancer. By examining the effects of exercise training in Veteran cancer survivors with NSCLC, there is the potential to revolutionize care for a: common, debilitating, and inadequately treated symptom in a growing population. This could lead to a larger investigation to fill critical gaps in the literature and at the same time help discover a new model of care for Veterans with chronic pain. The ultimate goal is to reduce this type of pain for the growing population of cancer survivors while simultaneously reducing the need for problematic opioid management. Type: Interventional Start Date: Aug 2019 |
Evaluating Novel Therapies in ctDNA Positive GI Cancers
Georgetown University
Colon Adenocarcinoma
Rectal Adenocarcinoma
Gastric Adenocarcinoma
Pancreatic Adenocarcinoma
Hepatocellular Carcinoma
This study is a non-randomized, open-label, multi-cohort, multi-site, pilot feasibility
therapeutic trial. The study will enroll 20 patients across 4 cohorts (CRC, gastric,
PDAC, and HCC/intra-hepatic-/extra-hepatic-, gall bladder adenocarcinomas) diagnosed with
histologically confirmed GI cancers.... expand
This study is a non-randomized, open-label, multi-cohort, multi-site, pilot feasibility therapeutic trial. The study will enroll 20 patients across 4 cohorts (CRC, gastric, PDAC, and HCC/intra-hepatic-/extra-hepatic-, gall bladder adenocarcinomas) diagnosed with histologically confirmed GI cancers. These patients will have already completed all Standard of Care (SOC) treatments (including neoadjuvant, surgery, local therapies, and/or adjuvant therapy as applicable), as defined by the treating primary physician or research team, with curative intent but have a positive SignateraTM tumor-informed ctDNA test and NED radiographically by standard imaging within 28 days prior to enrollment and within 1 year of completing all curative-intent therapy. All patients will be treated with intravenous (IV) atezolizumab 1200 mg IV and bevacizumab 15 mg/kg on Day 1 of 21-day cycles until disease recurrence, ctDNA POD, unacceptable toxicity, or subject withdrawal of consent with a maximum 12 month total duration of study therapy. Atezolizumab and bevacizumab drug will be provided. Type: Interventional Start Date: Mar 2023 |
CBT-I to Improve Functional Outcomes in Veterans With Psychosis
VA Office of Research and Development
Insomnia
Psychosis
The goal of this project is to examine the efficacy of Cognitive Behavioral Therapy for
Insomnia (CBT-I) for improving sleep and related functional outcomes in Veterans with
psychosis and insomnia. expand
The goal of this project is to examine the efficacy of Cognitive Behavioral Therapy for Insomnia (CBT-I) for improving sleep and related functional outcomes in Veterans with psychosis and insomnia. Type: Interventional Start Date: Nov 2021 |
Development of a City-Wide Cohort of HIV-Infected Persons in Care in the District of Columbia: The DC...
George Washington University
HIV
AIDS
The goal of the DC Cohort is to establish a clinic-based city-wide longitudinal cohort
that will describe clinical outcomes, and improve the quality of care for outpatients
with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) in
Washington, DC. expand
The goal of the DC Cohort is to establish a clinic-based city-wide longitudinal cohort that will describe clinical outcomes, and improve the quality of care for outpatients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) in Washington, DC. Type: Observational Start Date: Jan 2011 |
Transvaginal Low-level Laser Therapy to Improve Pelvic Pain and Sexual Function in Patients With Endometriosis.
Medstar Health Research Institute
Endometriosis
Dyspareunia
Pelvic Pain
Dyspareunia is defined as pain with penetrative sexual intercourse. Women with
endometriosis have a nine-fold increased risk of dyspareunia, when compared to the
general female population.
A prospective single-blinded randomized controlled trial will be performed evaluating the
change in pelvic... expand
Dyspareunia is defined as pain with penetrative sexual intercourse. Women with endometriosis have a nine-fold increased risk of dyspareunia, when compared to the general female population. A prospective single-blinded randomized controlled trial will be performed evaluating the change in pelvic pain and sexual satisfaction scores from baseline to 6 weeks after treatment with transvaginal photobiomodulation therapy or sham therapy. Treatment will involve 9 planned treatment sessions over 3-4 weeks. 40 women will be included in the study. Type: Interventional Start Date: May 2023 |
BXCL701 and Pembrolizumab in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Georgetown University
Metastatic Pancreatic Ductal Adenocarcinoma
Single-arm, open label study to determine the 18 week progression-free survival rate of
the combination of BXCL701 and pembrolizumab in patients with pancreatic ductal
adenocarcinoma in the second-line metastatic setting. expand
Single-arm, open label study to determine the 18 week progression-free survival rate of the combination of BXCL701 and pembrolizumab in patients with pancreatic ductal adenocarcinoma in the second-line metastatic setting. Type: Interventional Start Date: Aug 2023 |
Circulating Tumor DNA Enriched, Genomically Directed Post-neoadjuvant Trial for Patients With Residual...
Bryan Schneider, MD
Breast Cancer
Triple Negative Breast Cancer
This is a 3-arm study stratified by plasma ctDNA. Patients with residual TNBC disease
after pre-operative therapy will be assigned to 1 of 3 Arms based on plasma ctDNA
positivity and genomic marker(s). expand
This is a 3-arm study stratified by plasma ctDNA. Patients with residual TNBC disease after pre-operative therapy will be assigned to 1 of 3 Arms based on plasma ctDNA positivity and genomic marker(s). Type: Interventional Start Date: Aug 2021 |
Ketorolac vs Oxycodone for Great Toe Arthrodesis
Medstar Health Research Institute
Arthrodesis
This study reviews if taking ketorolac, after a joint fusion procedure, can decrease the
need for taking oxycodone (standard of care) for pain relief. The study also investigates
if ketorolac affects bone healing after surgery. expand
This study reviews if taking ketorolac, after a joint fusion procedure, can decrease the need for taking oxycodone (standard of care) for pain relief. The study also investigates if ketorolac affects bone healing after surgery. Type: Interventional Start Date: Apr 2020 |
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous...
Melanoma and Skin Cancer Trials Limited
Cutaneous Melanoma, Stage II
Patients with a primary invasive melanoma are recommended to undergo excision of the
primary lesion with a wide margin. There is evidence that less radical margins of
excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm
margin of excision of the primary lesion for... expand
Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of life. Type: Interventional Start Date: Dec 2019 |
Real-World Evaluation of Eko Murmur Analysis Software in a Point of Care Setting
Eko Devices, Inc.
Murmur, Heart
Innocent Murmurs
Heart Murmurs
Pathologic Murmur
The purpose of this research is to evaluate the impact of Eko AI plus EMAS (Eko Murmur
Analysis Software) on a clinician's referral decision in a real-world primary care
setting. There is an additional objective of understanding patient outcomes when patients
are referred for cardiology follow-up... expand
The purpose of this research is to evaluate the impact of Eko AI plus EMAS (Eko Murmur Analysis Software) on a clinician's referral decision in a real-world primary care setting. There is an additional objective of understanding patient outcomes when patients are referred for cardiology follow-up and/or echocardiogram. Type: Observational Start Date: Mar 2022 |
Transcatheter Aortic Prosthesis Function: A Long-term Follow-up Study
Medstar Health Research Institute
Aortic Valve Replacement
In this observational study, the investigators will enroll subjects who underwent TAVR or
SAVR more than 3 years ago. Clinical and procedural data from the implant/surgery will be
collected, alongside clinical and echocardiographic data from subsequent follow-up
visits. expand
In this observational study, the investigators will enroll subjects who underwent TAVR or SAVR more than 3 years ago. Clinical and procedural data from the implant/surgery will be collected, alongside clinical and echocardiographic data from subsequent follow-up visits. Type: Observational Start Date: Feb 2018 |
CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer
Exact Sciences Corporation
Colorectal Cancer
The CORRECT - MRD II study will prospectively enroll patients who have undergone complete
surgical resection for stage II or III colorectal cancer. Patients will be followed for a
minimum of 3 years and up to 5 years for recurrence. expand
The CORRECT - MRD II study will prospectively enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer. Patients will be followed for a minimum of 3 years and up to 5 years for recurrence. Type: Observational Start Date: Dec 2021 |
Measuring Impact of Computer Gaming on Arm Use in Rett Syndrome
Georgetown University
Rett Syndrome
Using a tele-research approach, we will recruit, enroll, guide and support carers and
participants to engage in computer based activities (modified virtual reality) with the
primary outcome of reducing stereotypies and increasing independent arm and hand use and
secondary outcome of improving quality... expand
Using a tele-research approach, we will recruit, enroll, guide and support carers and participants to engage in computer based activities (modified virtual reality) with the primary outcome of reducing stereotypies and increasing independent arm and hand use and secondary outcome of improving quality of living. Because of our virtual approach, we are able to recruit from multiple countries and all states and territories of the USA. Type: Interventional Start Date: May 2021 |
Quality of Life in Patients With Clinically Localized Prostate Cancer Treated With Radiosurgery
Georgetown University
Prostate Cancer
Localized Malignant Neoplasm
Quality of life data following SBRT for prostate cancer has been obtained in only a small
numbers of patients. A prospective study using validated quality of life questionnaires
is needed to determine outcomes after treatment with SBRT. Our study will be the first
essential step in developing a better... expand
Quality of life data following SBRT for prostate cancer has been obtained in only a small numbers of patients. A prospective study using validated quality of life questionnaires is needed to determine outcomes after treatment with SBRT. Our study will be the first essential step in developing a better evidence base on the comparative risks and benefits of SBRT treatment with regards to quality of life assessment and outcomes. Type: Observational Start Date: Dec 2012 |
2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
Centinel Spine
Symptomatic Cervical Disc Disease
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and
prodisc C Vivo to the control, a similar, legally marketed total disc replacement device
in subjects with symptomatic cervical disc disease (SCDD). expand
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease (SCDD). Type: Interventional Start Date: Aug 2019 |
DC Longitudinal Study on Aging and Specimen Bank
Georgetown University
Alzheimer Disease
Dementia
Mild Cognitive Impairment
Aging
Aging Disorder
The Georgetown University Memory Disorders Program, part of the Department of Neurology,
is conducting pilot studies of the feasibility of various diagnostic tests for
Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases.
Further, this study is assessing longitudinal... expand
The Georgetown University Memory Disorders Program, part of the Department of Neurology, is conducting pilot studies of the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases. Further, this study is assessing longitudinal changes in biological, lifestyle, and cognitive assessment collection. The primary goal of this study is to examine the feasibility of biochemical assays, genetic testing, and cognitive and lifestyle assessments in the ante-mortem diagnosis of Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases. This research involves genetic and cognitive status testing but the findings will not be shared with research subjects. This will be accomplished ex vivo using blood, and/or cerebrospinal fluid (CSF) specimens from patients with a diagnosis of probable Alzheimer's disease, mild cognitive impairment, or other neurodegenerative diseases and from normal controls. Type: Observational Start Date: Jan 2007 |
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
NRG Oncology
Stage III Colon Cancer
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to
patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery
for colon cancer. expand
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer. Type: Interventional Start Date: Mar 2022 |
Pan Tumor Rollover Study
Bristol-Myers Squibb
Cancer
Main Objective of this study is to examine long-term safety of nivolumab monotherapy
including combinations and other cancer therapies in various tumor types. expand
Main Objective of this study is to examine long-term safety of nivolumab monotherapy including combinations and other cancer therapies in various tumor types. Type: Interventional Start Date: Aug 2019 |
RevCore for In Stent Thrombosis
Inari Medical
In-stent Thrombosis
The purpose of this research is to collect information about how the RevCore Thrombectomy
Catheter works to treat stent blockages. expand
The purpose of this research is to collect information about how the RevCore Thrombectomy Catheter works to treat stent blockages. Type: Observational Start Date: Aug 2024 |
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events...
Eli Lilly and Company
Atherosclerotic Cardiovascular Disease (ASCVD)
Elevated Lp(a)
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing
cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular
disease or are at risk of a heart attack or stroke. The study drug will be administered
subcutaneously (SC) (under the skin). expand
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Type: Interventional Start Date: Mar 2024 |
Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)
Merck Sharp & Dohme LLC
Endometrial Cancer
Researchers are looking for new ways to treat people with endometrial cancer (EC) who
have previously received treatment with platinum based therapy (a type of chemotherapy)
and immunotherapy. Immunotherapy is a treatment that helps the immune system fight
cancer. This clinical study will compare... expand
Researchers are looking for new ways to treat people with endometrial cancer (EC) who have previously received treatment with platinum based therapy (a type of chemotherapy) and immunotherapy. Immunotherapy is a treatment that helps the immune system fight cancer. This clinical study will compare MK-2870 sacituzumab tirumotecan to chemotherapy. The goal of the study is to learn if people who receive MK-2870 sacituzumab tirumotecan live longer overall and without the cancer getting worse compared to people who receive chemotherapy. Type: Interventional Start Date: Dec 2023 |
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy...
Intellia Therapeutics
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
To evaluate the efficacy and safety of a single dose of NTLA-2001 compared to placebo in
participants with ATTR-CM. expand
To evaluate the efficacy and safety of a single dose of NTLA-2001 compared to placebo in participants with ATTR-CM. Type: Interventional Start Date: Dec 2023 |
Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)
Shockwave Medical, Inc.
Coronary Artery Disease
Myocardial Infarction
This investigational device exemption (IDE) study is to assess the safety and
effectiveness of the Shockwave Coronary Intravascular Lithotripsy (IVL) System with the
Shockwave C2+ 2Hz Coronary IVL Catheter to treat de novo, calcified, stenotic, coronary
lesions prior to stenting. expand
This investigational device exemption (IDE) study is to assess the safety and effectiveness of the Shockwave Coronary Intravascular Lithotripsy (IVL) System with the Shockwave C2+ 2Hz Coronary IVL Catheter to treat de novo, calcified, stenotic, coronary lesions prior to stenting. Type: Interventional Start Date: Dec 2023 |
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