Home-based Vision Rehabilitation Guided by Brain Imaging
Purpose
The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss. Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.
Conditions
- Visual Field Defect
- Stroke
- Hemianopia Homonymous
- Quadrantanopia
- Cortical Blindness
- Visual Field Defect, Peripheral
- Visual Field Loss
- Traumatic Brain Injury
- Brain Tumor
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- At least 18 years of age. 2. Capable of providing informed consent and complying with study procedures. 3. Unilateral or bilateral focal brain damage causing visual field loss. 4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year. 5. Eligible for MRI based on standard safety screening.
Exclusion Criteria
- Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation. 2. Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5. 3. Ocular disease or disorder.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Intervention Model Description
- Study Procedures Week 1: Pre-intervention visual assessment and functional magnetic resonance imaging (fMRI) scan (in-person study visit). Weeks 2-4: Participants complete at-home, online perceptual learning training using either low-level or high-level visual stimuli. End of Week 4: Online assessment to evaluate the spatial transfer of training effects. Weeks 5-6: Washout period to minimize potential carryover effects. Weeks 7-9: Participants complete the alternate at-home, online perceptual learning training condition (low-level or high-level visual stimuli). End of Week 9: Second online assessment to evaluate the spatial transfer of training effects. Week 10 (Final Visit): Post-intervention visual assessment and fMRI scan (in-person study visit). Approximately Week 24: Follow-up visual assessment and fMRI scan (in-person study visit). The timing of study visits and training sessions may be adjusted as needed to accommodate participants' health status, scheduling needs, or o
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Perceptual learning-based training using high-level visual stimuli |
A 3 week at-home online perceptual learning-based training using high-level visual stimuli. |
|
|
Active Comparator Perceptual learning-based training using low-level visual stimuli |
A 3 week at-home online perceptual learning-based training using low-level visual stimuli. |
|
Recruiting Locations
Georgetown University Medical Center
Washington D.C., District of Columbia 20057
Washington D.C., District of Columbia 20057
More Details
- Status
- Recruiting
- Sponsor
- Georgetown University