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Purpose

Among Veterans, the prevalence of chronic kidney disease (CKD) is reported to be as high as 47.3% and a third higher than the general population. Muscle wasting and dysfunction have been identified as primary consequences of CKD. Disease-induced reductions in lean tissue adversely affect muscle fatigability. Consequently, muscle fatigability may serve as a potential limiting factor that contributes to activity limitations. However, there is a lack of evidence informing our understanding of muscle fatigability in patients with CKD. Dialysis treatment is a major factor contributing to the high financial costs of CKD care. Thus, in addition to potential health and quality of life benefits, treatments capable of maintaining kidney function or delaying the onset of dialysis treatment would provide substantial socio-economic benefit. Both lean body mass and muscle fatigability may be improved through strength training. Eccentric-overload (i.e. muscle lengthening) progressive resistance exercise (PRE) has been shown to be safe and effective for a variety of chronic conditions. Eccentric PRE using portable flywheel technology may provide a clinically viable treatment option to combat muscle impairments in CKD given the cost effectiveness and minimal space requirements for this mode of exercise. The purpose of this study is to assess feasibility of the eccentric-overload PRE regimen for Veterans with CKD stage 3 & 4 predialysis using a prospective single-arm pre-test post-test intervention design. The primary aim of the project is to determine the effects of eccentric-overload PRE on muscle fatigability in Veterans with CKD Stages 3 & 4 predialysis. Feasibility of the regimen will be determined by the time needed to complete the 4-exercise regimen and the perceived exertion levels reported by the study participants.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 84 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • ambulatory patients (with or without a gait aid) - CKD stage 3 or 4 - patients receiving care at the DC VAMC Renal Service - the ability to speak and read English - orientation to person, place, and time

Exclusion Criteria

  • unable to speak English - acute renal failure - pregnant - unable to follow study instructions - any uncontrolled cardiovascular or musculoskeletal problems that would make participation in this study unsafe

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Other
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Eccentric overload exercise
  • Behavioral: Eccentric overload exercise
    12 weeks of 2x per week of the following eccentric exercises: squat, shoulder press, row, and bicep curl.

Recruiting Locations

Washington DC VA Medical Center
Washington, District of Columbia 20422
Contact:
Jared M Gollie, PhD
202-745-8000
Jared.Gollie@va.gov

More Details

Status
Unknown status
Sponsor
Washington D.C. Veterans Affairs Medical Center

Study Contact

Jared M Gollie, PhD
202-745-8000
Jared.Gollie@va.gov

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.