Search Clinical Trials
Below please find a list of studies actively recruiting volunteers at one of the following GHUCCTS institutions: Georgetown University, Howard University, MedStar Health Research Institute, or Washington DC VA Medical Center. Please enter your search criteria below to help find a study for you. If you have any questions, please email us or call us at 301-560-2963.
Sponsor Condition of Interest |
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Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry
Chiesi USA, Inc.
Myocardial Infarction
The purpose of this registry is to address optimal platelet inhibition during the early
management of MI patients prior to coronary angiography or CABG. expand
The purpose of this registry is to address optimal platelet inhibition during the early management of MI patients prior to coronary angiography or CABG. Type: Observational Start Date: Oct 2019 |
Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial
Johns Hopkins University
Multiple Sclerosis, Relapsing-Remitting
FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the
relapsing phase of MS but have minimal impact once the progressive phase has begun. It is
unclear if, in the relapsing phase, there is an advantage of early aggressive therapy
with respect to preventing long-term disability.... expand
FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability. The infectious risks and other complications associated with higher-efficacy treatments highlight the need to quantify their effectiveness in preventing disability. The TRaditional versus Early Aggressive Therapy for MS (TREAT-MS) trial is a pragmatic, randomized controlled trial that has two primary aims: 1) to evaluate, jointly and independently among patients deemed at higher risk vs. lower risk for disability accumulation, whether an "early aggressive" therapy approach, versus starting with a traditional, first-line therapy, influences the intermediate-term risk of disability, and 2) to evaluate if, among patients deemed at lower risk for disability who start on first-line MS therapies but experience breakthrough disease, those who switch to a higher-efficacy versus a new first-line therapy have different intermediate-term risk of disability. Type: Interventional Start Date: May 2018 |
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer
Canadian Cancer Trials Group
Breast Cancer
The purpose of this study is to compare the effects on low risk breast cancer receiving
usual care that includes regional radiation therapy, with receiving no regional radiation
therapy. Researchers want to see if not giving this type of radiation treatment works as
well at preventing breast cancer... expand
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back. Type: Interventional Start Date: Oct 2018 |
Peer-Led Diet and Exercise Intervention
VA Office of Research and Development
Physical Activity
Peer Leaders
Diet Quality
The majority of older Veterans do not meet the minimum healthy diet or physical activity
recommendations, despite known benefits. Identifying novel ways to increase adherence to
rehabilitation programs that improve dietary quality and physical activity may reduce the
risk of disability in older Veterans.... expand
The majority of older Veterans do not meet the minimum healthy diet or physical activity recommendations, despite known benefits. Identifying novel ways to increase adherence to rehabilitation programs that improve dietary quality and physical activity may reduce the risk of disability in older Veterans. Peer-based interventions may be one method to facilitate lasting behavioral change since peers often share a common culture and knowledge about the problems that their community experiences. The investigators propose to develop and evaluate a novel peer-led diet and exercise intervention that targets older Veterans with multiple chronic health conditions. Successful development and pilot of this intervention will provide the preliminary data for a larger multisite trial focused on the use of peer-led interventions to improve long-term compliance to lifestyle interventions in older Veterans. Type: Interventional Start Date: Aug 2023 |
A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension...
Inventiva Pharma
NASH - Nonalcoholic Steatohepatitis
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver
fibrosis histological stage F2 or F3 expand
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3 Type: Interventional Start Date: Aug 2021 |
A Study of Selinexor, in Combination With Carfilzomib, Daratumumab or Pomalidomide in Patients With Multiple...
Hackensack Meridian Health
Multiple Myeloma
This is a prospective, 2-arm (with an additional exploratory arm), open-label,
multicenter study looking at the response rate of patients receiving selinexor (KPT-330),
in combination with carfilzomib, daratumumab or pomalidomide.
Multiple Myeloma patients with documented disease progression or... expand
This is a prospective, 2-arm (with an additional exploratory arm), open-label, multicenter study looking at the response rate of patients receiving selinexor (KPT-330), in combination with carfilzomib, daratumumab or pomalidomide. Multiple Myeloma patients with documented disease progression or refractory disease while on current treatment with any carfilzomib-containing regimen (arm 1), any pomalidomide-containing regimen (arm 2) or any daratumumab-containing regimen (exploratory arm) will be included in the study. Patients will be assigned to the respective groups according to their current treatment. If a subject has received more than one of the above therapies, then assignment will be made at their physician's discretion (e.g treatment decision can be made based upon patient and physician preferred tolerance.). Patients will receive treatment until progressive disease (PD), death, toxicity that cannot be managed by standard of care, or withdrawal, whichever occurs first. Type: Interventional Start Date: Mar 2021 |
Fecal Microbiota Transplant National Registry
American Gastroenterological Association
Fecal Microbiota Transplantation
Clostridium Difficile Infection
Gut Microbiome
A national data registry of patients receiving fecal microbiota transplantation (FMT) or
other gut-related-microbiota products designed to prospectively assess short and
long-term safety and effectiveness expand
A national data registry of patients receiving fecal microbiota transplantation (FMT) or other gut-related-microbiota products designed to prospectively assess short and long-term safety and effectiveness Type: Observational [Patient Registry] Start Date: Sep 2017 |
A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy)
Merus N.V.
Solid Tumours Harboring NRG1 Fusion
NSCLC Harboring NRG1 Fusion
Pancreatic Cancer Harboring NRG1 Fusion
NRG1 Fusion
This is a Phase I/II, open-label, multi-center, multi-national, dose escalation, single
agent study to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor
activity of zenocutuzumab (MCLA-128) in patients with solid tumors harboring an NRG1
fusion (eNRGy) expand
This is a Phase I/II, open-label, multi-center, multi-national, dose escalation, single agent study to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor activity of zenocutuzumab (MCLA-128) in patients with solid tumors harboring an NRG1 fusion (eNRGy) Type: Interventional Start Date: Jan 2015 |
HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections...
Inflammatix
Respiratory Tract Infections
Urinary Tract Infections
Intra-Abdominal Infections
Skin and Soft Tissue Infection
Suspected Meningitis/Encephalitis or Any Other Infection
This study will analyze gene expression and other laboratory data from biological samples
collected from participants with suspected respiratory, urinary, intra-abdominal, and/or
skin & soft tissue infections; or suspected sepsis of any cause. expand
This study will analyze gene expression and other laboratory data from biological samples collected from participants with suspected respiratory, urinary, intra-abdominal, and/or skin & soft tissue infections; or suspected sepsis of any cause. Type: Observational Start Date: Feb 2020 |
Exercise Rehabilitation in Veteran Cancer Survivors
VA Office of Research and Development
Cancer
Exercise rehabilitation has the potential as a non-pharmacological approach to reduce
persistent neuropathic pain in Veterans with lung cancer. By examining the effects of
exercise training in Veteran cancer survivors with NSCLC, there is the potential to
revolutionize care for a: common, debilitating,... expand
Exercise rehabilitation has the potential as a non-pharmacological approach to reduce persistent neuropathic pain in Veterans with lung cancer. By examining the effects of exercise training in Veteran cancer survivors with NSCLC, there is the potential to revolutionize care for a: common, debilitating, and inadequately treated symptom in a growing population. This could lead to a larger investigation to fill critical gaps in the literature and at the same time help discover a new model of care for Veterans with chronic pain. The ultimate goal is to reduce this type of pain for the growing population of cancer survivors while simultaneously reducing the need for problematic opioid management. Type: Interventional Start Date: Aug 2019 |
Evaluating Novel Therapies in ctDNA Positive GI Cancers
Georgetown University
Colon Adenocarcinoma
Rectal Adenocarcinoma
Gastric Adenocarcinoma
Pancreatic Adenocarcinoma
Hepatocellular Carcinoma
This study is a non-randomized, open-label, multi-cohort, multi-site, pilot feasibility
therapeutic trial. The study will enroll 20 patients across 4 cohorts (CRC, gastric,
PDAC, and HCC/intra-hepatic-/extra-hepatic-, gall bladder adenocarcinomas) diagnosed with
histologically confirmed GI cancers.... expand
This study is a non-randomized, open-label, multi-cohort, multi-site, pilot feasibility therapeutic trial. The study will enroll 20 patients across 4 cohorts (CRC, gastric, PDAC, and HCC/intra-hepatic-/extra-hepatic-, gall bladder adenocarcinomas) diagnosed with histologically confirmed GI cancers. These patients will have already completed all Standard of Care (SOC) treatments (including neoadjuvant, surgery, local therapies, and/or adjuvant therapy as applicable), as defined by the treating primary physician or research team, with curative intent but have a positive SignateraTM tumor-informed ctDNA test and NED radiographically by standard imaging within 28 days prior to enrollment and within 1 year of completing all curative-intent therapy. All patients will be treated with intravenous (IV) atezolizumab 1200 mg IV and bevacizumab 15 mg/kg on Day 1 of 21-day cycles until disease recurrence, ctDNA POD, unacceptable toxicity, or subject withdrawal of consent with a maximum 12 month total duration of study therapy. Atezolizumab and bevacizumab drug will be provided. Type: Interventional Start Date: Mar 2023 |
CBT-I to Improve Functional Outcomes in Veterans With Psychosis
VA Office of Research and Development
Insomnia
Psychosis
The goal of this project is to examine the efficacy of Cognitive Behavioral Therapy for
Insomnia (CBT-I) for improving sleep and related functional outcomes in Veterans with
psychosis and insomnia. expand
The goal of this project is to examine the efficacy of Cognitive Behavioral Therapy for Insomnia (CBT-I) for improving sleep and related functional outcomes in Veterans with psychosis and insomnia. Type: Interventional Start Date: Nov 2021 |
Development of a City-Wide Cohort of HIV-Infected Persons in Care in the District of Columbia: The DC...
George Washington University
HIV
AIDS
The goal of the DC Cohort is to establish a clinic-based city-wide longitudinal cohort
that will describe clinical outcomes, and improve the quality of care for outpatients
with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) in
Washington, DC. expand
The goal of the DC Cohort is to establish a clinic-based city-wide longitudinal cohort that will describe clinical outcomes, and improve the quality of care for outpatients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) in Washington, DC. Type: Observational Start Date: Jan 2011 |
Transvaginal Low-level Laser Therapy to Improve Pelvic Pain and Sexual Function in Patients With Endometriosis.
Medstar Health Research Institute
Endometriosis
Dyspareunia
Pelvic Pain
Dyspareunia is defined as pain with penetrative sexual intercourse. Women with
endometriosis have a nine-fold increased risk of dyspareunia, when compared to the
general female population.
A prospective single-blinded randomized controlled trial will be performed evaluating the
change in pelvic... expand
Dyspareunia is defined as pain with penetrative sexual intercourse. Women with endometriosis have a nine-fold increased risk of dyspareunia, when compared to the general female population. A prospective single-blinded randomized controlled trial will be performed evaluating the change in pelvic pain and sexual satisfaction scores from baseline to 6 weeks after treatment with transvaginal photobiomodulation therapy or sham therapy. Treatment will involve 9 planned treatment sessions over 3-4 weeks. 40 women will be included in the study. Type: Interventional Start Date: May 2023 |
BXCL701 and Pembrolizumab in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Georgetown University
Metastatic Pancreatic Ductal Adenocarcinoma
Single-arm, open label study to determine the 18 week progression-free survival rate of
the combination of BXCL701 and pembrolizumab in patients with pancreatic ductal
adenocarcinoma in the second-line metastatic setting. expand
Single-arm, open label study to determine the 18 week progression-free survival rate of the combination of BXCL701 and pembrolizumab in patients with pancreatic ductal adenocarcinoma in the second-line metastatic setting. Type: Interventional Start Date: Aug 2023 |
Circulating Tumor DNA Enriched, Genomically Directed Post-neoadjuvant Trial for Patients With Residual...
Bryan Schneider, MD
Breast Cancer
Triple Negative Breast Cancer
This is a 3-arm study stratified by plasma ctDNA. Patients with residual TNBC disease
after pre-operative therapy will be assigned to 1 of 3 Arms based on plasma ctDNA
positivity and genomic marker(s). expand
This is a 3-arm study stratified by plasma ctDNA. Patients with residual TNBC disease after pre-operative therapy will be assigned to 1 of 3 Arms based on plasma ctDNA positivity and genomic marker(s). Type: Interventional Start Date: Aug 2021 |
Ketorolac vs Oxycodone for Great Toe Arthrodesis
Medstar Health Research Institute
Arthrodesis
This study reviews if taking ketorolac, after a joint fusion procedure, can decrease the
need for taking oxycodone (standard of care) for pain relief. The study also investigates
if ketorolac affects bone healing after surgery. expand
This study reviews if taking ketorolac, after a joint fusion procedure, can decrease the need for taking oxycodone (standard of care) for pain relief. The study also investigates if ketorolac affects bone healing after surgery. Type: Interventional Start Date: Apr 2020 |
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous...
Melanoma and Skin Cancer Trials Limited
Cutaneous Melanoma, Stage II
Patients with a primary invasive melanoma are recommended to undergo excision of the
primary lesion with a wide margin. There is evidence that less radical margins of
excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm
margin of excision of the primary lesion for... expand
Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of life. Type: Interventional Start Date: Dec 2019 |
Real-World Evaluation of Eko Murmur Analysis Software in a Point of Care Setting
Eko Devices, Inc.
Murmur, Heart
Innocent Murmurs
Heart Murmurs
Pathologic Murmur
The purpose of this research is to evaluate the impact of Eko AI plus EMAS (Eko Murmur
Analysis Software) on a clinician's referral decision in a real-world primary care
setting. There is an additional objective of understanding patient outcomes when patients
are referred for cardiology follow-up... expand
The purpose of this research is to evaluate the impact of Eko AI plus EMAS (Eko Murmur Analysis Software) on a clinician's referral decision in a real-world primary care setting. There is an additional objective of understanding patient outcomes when patients are referred for cardiology follow-up and/or echocardiogram. Type: Observational Start Date: Mar 2022 |
Transcatheter Aortic Prosthesis Function: A Long-term Follow-up Study
Medstar Health Research Institute
Aortic Valve Replacement
In this observational study, the investigators will enroll subjects who underwent TAVR or
SAVR more than 3 years ago. Clinical and procedural data from the implant/surgery will be
collected, alongside clinical and echocardiographic data from subsequent follow-up
visits. expand
In this observational study, the investigators will enroll subjects who underwent TAVR or SAVR more than 3 years ago. Clinical and procedural data from the implant/surgery will be collected, alongside clinical and echocardiographic data from subsequent follow-up visits. Type: Observational Start Date: Feb 2018 |
CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer
Exact Sciences Corporation
Colorectal Cancer
The CORRECT - MRD II study will prospectively enroll patients who have undergone complete
surgical resection for stage II or III colorectal cancer. Patients will be followed for a
minimum of 3 years and up to 5 years for recurrence. expand
The CORRECT - MRD II study will prospectively enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer. Patients will be followed for a minimum of 3 years and up to 5 years for recurrence. Type: Observational Start Date: Dec 2021 |
Measuring Impact of Computer Gaming on Arm Use in Rett Syndrome
Georgetown University
Rett Syndrome
Using a tele-research approach, we will recruit, enroll, guide and support carers and
participants to engage in computer based activities (modified virtual reality) with the
primary outcome of reducing stereotypies and increasing independent arm and hand use and
secondary outcome of improving quality... expand
Using a tele-research approach, we will recruit, enroll, guide and support carers and participants to engage in computer based activities (modified virtual reality) with the primary outcome of reducing stereotypies and increasing independent arm and hand use and secondary outcome of improving quality of living. Because of our virtual approach, we are able to recruit from multiple countries and all states and territories of the USA. Type: Interventional Start Date: May 2021 |
Quality of Life in Patients With Clinically Localized Prostate Cancer Treated With Radiosurgery
Georgetown University
Prostate Cancer
Localized Malignant Neoplasm
Quality of life data following SBRT for prostate cancer has been obtained in only a small
numbers of patients. A prospective study using validated quality of life questionnaires
is needed to determine outcomes after treatment with SBRT. Our study will be the first
essential step in developing a better... expand
Quality of life data following SBRT for prostate cancer has been obtained in only a small numbers of patients. A prospective study using validated quality of life questionnaires is needed to determine outcomes after treatment with SBRT. Our study will be the first essential step in developing a better evidence base on the comparative risks and benefits of SBRT treatment with regards to quality of life assessment and outcomes. Type: Observational Start Date: Dec 2012 |
2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
Centinel Spine
Symptomatic Cervical Disc Disease
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and
prodisc C Vivo to the control, a similar, legally marketed total disc replacement device
in subjects with symptomatic cervical disc disease (SCDD). expand
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease (SCDD). Type: Interventional Start Date: Aug 2019 |
DC Longitudinal Study on Aging and Specimen Bank
Georgetown University
Alzheimer Disease
Dementia
Mild Cognitive Impairment
Aging
Aging Disorder
The Georgetown University Memory Disorders Program, part of the Department of Neurology,
is conducting pilot studies of the feasibility of various diagnostic tests for
Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases.
Further, this study is assessing longitudinal... expand
The Georgetown University Memory Disorders Program, part of the Department of Neurology, is conducting pilot studies of the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases. Further, this study is assessing longitudinal changes in biological, lifestyle, and cognitive assessment collection. The primary goal of this study is to examine the feasibility of biochemical assays, genetic testing, and cognitive and lifestyle assessments in the ante-mortem diagnosis of Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases. This research involves genetic and cognitive status testing but the findings will not be shared with research subjects. This will be accomplished ex vivo using blood, and/or cerebrospinal fluid (CSF) specimens from patients with a diagnosis of probable Alzheimer's disease, mild cognitive impairment, or other neurodegenerative diseases and from normal controls. Type: Observational Start Date: Jan 2007 |
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